46
13
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T11557 |
FASN-IN-3
|
Fatty Acid Synthase | Metabolism |
FASN-IN-3 是脂肪酸合酶抑制剂。 | |||
T7947 |
FT113
|
Fatty Acid Synthase | Metabolism |
FT113 是口服具有活力的脂肪酸合酶抑制剂,对全长重组人 FASN 酶的 IC50=213 nM。在 BT474 细胞中,它抑制 FASN 的特性,IC50=90 nM。它具有抗增殖作用,在体内和体外实验中,都具有抗癌作用。 | |||
T0686 |
Orlistat
Ro-18-0647,奥利司他,Tetrahydrolipstatin |
Apoptosis; Others; Fatty Acid Synthase | Apoptosis; Metabolism; Others |
Orlistat (Tetrahydrolipstatin) 是一种不可逆的胰腺和胃脂肪酶抑制剂,也是一种脂肪酸合成酶抑制剂,可研究肥胖症,具有抗动脉粥样硬化作用。 | |||
T17181 |
TVB-3664
|
Fatty Acid Synthase | Metabolism |
TVB-3664 是一种具有口服具有活力的、选择性的、可逆的、具有高生物利用度的脂肪酸合酶抑制剂,其对人和老鼠棕榈酸酯合成的IC50分别为 18 nM 和 12 nM。可显著抑制微管蛋白棕榈酰化和 mRNA 表达。 | |||
T17180 |
TVB-3166
|
Apoptosis; Others; Fatty Acid Synthase | Apoptosis; Metabolism; Others |
TVB-3166 是一种口服有效的,可逆和选择性脂肪酸合成酶 (FASN) 抑制剂,对于 FASN 和细胞棕榈酸酯合成的IC50分别为 42 nM 和 81 nM。它诱导细胞凋亡,抑制体内异种移植肿瘤生长。 | |||
T7798 |
FGH10019
FGH-10019 |
NPC1L1; Fatty Acid Synthase | Membrane transporter/Ion channel; Metabolism |
FGH10019 是固醇调节元件结合蛋白 (SREBP) 抑制剂,IC50=1 μM。 | |||
T9266 |
Fatostatin
|
Lipid; Fatty Acid Synthase | Metabolism |
Fatostatin A 是一种SREBP 活化的特异性抑制剂,能够抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合,抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤活性,能抑制ob/ob 小鼠的高血糖。它抑制细胞中成脂基因的转录。 | |||
T11267 |
FASN-IN-1
TVB-2460 |
Fatty Acid Synthase | Metabolism |
FASN- in -1是一种有效的、特异性的脂肪酸合成酶(FASN)抑制剂,是一种专门设计用于靶向和抑制FASN 活性的化合物,是一种参与脂肪酸合成的酶,可抑制FASN 活性可以破坏脂肪酸的产生,并可能影响各种细胞过程。 | |||
T12437 |
PF429242 dihydrochloride
|
S1P Receptor | GPCR/G Protein |
PF429242 dihydrochloride 是一种可逆的竞争性 SREBP 位点 1 蛋白酶抑制剂,IC50值为175 nM。 | |||
T36841 |
IPI-9119
|
Fatty Acid Synthase | Metabolism |
IPI-9119 是一种具有口服活性、选择性和不可逆的 FASN 抑制剂 (IC50 = 0.3 nM)。 | |||
T10656 |
trans-C75
(±)-C75,反-4-羧基-5-辛基-3-甲基-丁内酯 |
Others; Fatty Acid Synthase | Metabolism; Others |
trans-C75 ((±)-C75) 是一种 C75 的对映异构体。其中 C75 是一种脂肪酸合成酶 (FASN) 的抑制剂。 | |||
T15271 |
Denifanstat
FASN-IN-2,TVB2640,TVB-2640 |
Fatty Acid Synthase | Metabolism |
Denifanstat (FASN-IN-2) 是一种口服具有活性的选择性 FASN 抑制剂,IC50=0.052 μM,EC50=0.072 μM。它有用于脂肪肝和癌症的研究潜力。 | |||
T6832 |
Fatostatin hydrobromide
Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin |
NPC1L1; Fatty Acid Synthase | Membrane transporter/Ion channel; Metabolism |
Fatostatin hydrobromide (Fatostatin A HBr) 是一种 SREBP 活化的特异性抑制剂,可抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合,抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤作用,能抑制 ob/ob 小鼠的高血糖。它抑制了细胞中成脂基因的转录。 | |||
T10657 |
C75
C-75 |
Fatty Acid Synthase | Metabolism |
C75 是一种合成脂肪酸合酶 (FASN) 抑制剂,可抑制前列腺癌细胞 PC3 (IC50: 35 μM)。 | |||
T15429 |
GSK2194069
|
Others; NADPH; Fatty Acid Synthase | Metabolism; Others |
GSK2194069 是 一种具有活性的脂肪酸合成酶 (FASN) 的 β-酮基还原酶 (KR)特异性抑制剂,在检测释放的 CoA 的试验中测的 IC50 为7.7 nM。GSK2194069 通过作用于乙酰乙酰辅酶 A 和 NADPH 来抑制 FAS 的癌细胞增殖。 | |||
T21831 |
UCM05
G28UCM |
Fatty Acid Synthase | Metabolism |
UCM05 (G28UCM) (G28UCM) 是一种有效的脂肪酸合酶 (FASN) 抑制剂,对 HER2+ 乳腺癌异种移植物具有作用活性,且在抗 HER2 耐药细胞系中具有活性。UCM05 是一种丝状温度敏感蛋白 Z (FtsZ) 抑制剂,可抑制革兰氏阳性菌B. subtilis 生长,MIC 值为 100 μM,但对革兰氏阴性菌E. coli 缺乏活性。 | |||
T26458 |
A 9145C
A9145C,A-9145C |
||
A 9145C is an inhibitor of RNA methylase and cyclopropane fatty acid synthase. | |||
T11266 |
FASN-IN-4
FAS-IN-1 |
Others | Others |
FAS-IN-1 is a potent inhibitor of Fatty acid synthase (FAS) wtih IC50 of 10 nM. | |||
T11266L |
FAS-IN-1 Tosylate
|
Fatty Acid Synthase | Metabolism |
FAS-IN-1 Tosylate is an effective fatty acid synthase inhibitor;Has an IC50 of 10 nM. | |||
T29343 |
2-Decenoic acid
Dec-2-enoic acid |
||
trans-Dec-2-enoic acid is an intermediate in fatty acid biosynthesis. Specifically, trans-Dec-2-enoic is converted from (R)-3-Hydroxydecanoic acid via enzyme, fatty-acid Synthase (EC:2. 3. 1. 85). | |||
T27495 |
GSK951A
|
||
GSK951A is an inhibitor of EchA6. GSK951A interacts with fatty acid synthase II (FAS-II), inhibits mycolic acid biosynthesis and suppresses the synthesis of all classes of MAMES in M. bovis BCG, whilst the FAMEs remain largely unaffected. | |||
T11575 |
HS80
|
Others | Others |
HS-80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids (IC50: 7.13 μM). | |||
T14570 |
BI 99179
BI99179 |
Fatty Acid Synthase | Metabolism |
BI99179 is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM and it exhibits significant exposure (both peripheral and central) upon oral administration in rats[1]. | |||
T11574 | HS79 | Others | Others |
HS-79 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-79 is able to inhibit the incorporation of tritiated acetate into lipids (IC50: 1.57 μM). | |||
T35634 |
Platensimycin
|
||
Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively). By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic ... | |||
T37776 | FASN-IN-4 tosylate | ||
FASN-IN-4 tosylate 是高效的脂肪酸合酶 FASN 抑制剂,IC50值为 10 nM。FASN-IN-4 tosylate 还抑制 SARS-CoV-2,EC50为 18.6 nM。 | |||
T35697 |
Lauric Acid-13C
|
||
Lauric acid-13C is intended for use as an internal standard for the quantification of lauric acid by GC- or LC-MS. Lauric acid is a medium-chain saturated fatty acid. It has been found at high levels in coconut oil.1Lauric acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.2 | |||
T64276 | Octanoyl coenzyme A lithium | ||
Octanoyl coenzyme A lithium 是一种脂肪酸酰基辅酶 A 的衍生物。Octanoyl coenzyme A lithium 能够抑制柠檬酸合成酶和谷氨酸脱氢酶 (IC50: 0.4-1.6 mM)。 | |||
T36045 |
1a,1b-dihomo Prostaglandin E2
1a,1b-dihomo Prostaglandin E2 |
||
1a,1b-dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid . 1a,1b-dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid . This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase. | |||
T70978 | 5-Hydroxy Lansoprazole Sulfide | ||
5-Hydroxy Lansoprazole Sulfide is an inhibitor of fatty acid synthase (FASN). FASN, which is responsible for de-novo synthesis of lipids, has been found to be overexpressed in cancerous tissue. 5-Hydroxy Lansoprazole Sulfide specifically inhibits enoyl reductase, and was found to more effectively inhibit FASN function than lansoprazole and was also more efficient at regulating NHEJ repair of oxidative DNA damage via PARP1. | |||
T37405 | Octanoyl Coenzyme A (sodium salt) | ||
Octanoyl coenzyme A (octanoyl-CoA) is a medium-chain acyl CoA and a metabolic intermediate in mitochondrial fatty acid β-oxidation. Levels of octanoyl-CoA are increased in the liver of patients with Reye's syndrome and β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH) is decreased in patients with MCADH deficiency (MCD). Octanoyl-CoA inhibits citrate synthase and glutamate dehydrogenase. | |||
T38208 |
Heneicosapentaenoic Acid
|
||
Heneicosapentaenoic Acid (HPA) is a 21:5 ω-3 fatty acid present in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one carbon on the carboxyl end, placing the first double bond in the δ6 position. HPA can be used to study the significance of the position of the double bonds in ω-3 fatty acids. It incorporates into phospholipids and into triacylglycerol in vivo with the same efficiency as EPA and... | |||
T78873 |
CTL-12
|
||
CTL-12是一种Fatty Acid Synthase (FASN)抑制剂(IC50: 2.5 μM),能够诱导apoptosis。它使细胞周期在Sub-G1/S期停滞并增加caspase-9和凋亡标志物Bax的表达,同时减少抗凋亡标志物Bcl-xL的水平。CTL-12通过抑制de novo脂肪酸合成,切断了肿瘤细胞的代谢需求,是乳腺癌和结直肠癌研究中的重要工具。 | |||
T37867 |
9(S)-HpOTrE
|
||
9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid. It can be further metabolized to colnelenic acid by a divinyl ether synthase activity found in garlic and potato microsomal fractions. 9(S)-HpOTrE also serves as a substrate for further oxidation by both soybean and potato LOs, resulting in the formation of 9,16-dihydroperoxy acid. The suicide inactivation of LOs when 9(S)-HpOTrE is used as a substrate is thought to oc... | |||
T37270 |
9(E),11(E)-12-nitro Conjugated Linoleic Acid
|
||
9(E),11(E)-12-nitro Conjugated linoleic acid (9(E),11(E)-12-nitro CLA) is a nitrated fatty acid. It is formed from 9(Z),11(E)-CLA upon exposure to acidified nitrite, peroxynitrite, gaseous nitrogen dioxide, or a combination of myeloperoxidase, hydrogen peroxide, and nitrite.1It is also formed in LPS-stimulated RAW 264.7 macrophages, an effect that can be reduced by the nitric oxide synthase (NOS) inhibitor L-NAME .29(E),11(E)-12-nitro CLA has been found in human plasma. 1.Woodcock, S.R., Salvato... | |||
T12342 |
P053
|
Others | Others |
P053 是一种有效的,非竞争性和选择性的神经酰胺合酶1 (CerS1) 抑制剂(IC50= 0.5 μM)。P053 作为肌肉线粒体脂肪酸氧化的内源性抑制剂和全身肥胖调节剂。 | |||
T78872 |
CTL-06
|
||
CTL-06是一种Fatty Acid Synthase (FASN)抑制剂,具有3 μM的IC50,能够诱发细胞凋亡。CTL-12导致细胞周期在Sub-G1/S期停滞,并增加caspase-9和凋亡标志物Bax的表达,减少抗凋亡标志物Bcl-xL的表达。此外,CTL-12通过抑制脂肪酸的从头合成,剥夺肿瘤细胞代谢所需,主要用于乳腺癌和结直肠癌的研究。 | |||
T38389 |
Prostaglandin D2 Ethanolamide
Prostaglandin D2 Ethanolamide |
||
Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of minia... | |||
T70882 |
Orlistat-d3
|
||
Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit... | |||
T35791 | Palmitic acid-13C | ||
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ... | |||
T35789 | Palmitic acid-1-13C | ||
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 |1. Santos, M.J., López-Jurado, M., Llopis, J., et a... | |||
T37743 |
N-octadecanoyl-L-Homoserine lactone
|
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener... | |||
T35979 |
Benastatin C
|
||
Benastatin C is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2It inhibits glutathione S-transferase (GST; IC50= 24 μg/ml for the rat liver enzyme).2Benastatin C also inhibits the esterase activity of isolated porcine pancreatic lipase (IC50= 10 μg/ml). It increases LPS- or concanavalin A-induced blastogenesis of isolated mouse spleen lymphocytes in a concentration-dependent manner. 1.Xu, Z., Schenk, A., and Hertweck, C.Molecul... | |||
T36130 |
22(S)-hydroxy Cholesterol
22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol |
||
22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22... | |||
T35978 | Benastatin A | ||
Benastatin A is a polyketide synthase-derived benastatin that has been found inStreptomycesand has diverse biological activities.1,2,3It inhibits glutathione S-transferase (GST; Ki= 5 μM for the rat liver enzyme).2Benastatin A is active against several bacteria, including methicillin-resistantS. aureus(MRSA; MIC = 3.12 μg/ml). It induces apoptosis and cell cycle arrest at the G1/G0phase in Colon 26 mouse colon cancer cells when used at concentrations of 20 and 16 μM, respectively.3 1.Xu, Z., Sch... | |||
T37741 |
N-hexadecanoyl-L-Homoserine lactone
C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone |
||
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0260 |
Cerulenin
|
Antibiotic; Antifungal; Fatty Acid Synthase | Metabolism; Microbiology/Virology |
Cerulenin 是广泛使用的天然脂肪酸合成酶抑制剂。它是由真菌Cephalosporium caeruleus 产生的。它抑制拓扑异构酶I 催化活性并增强 SN-38 诱导的细胞凋亡。它具有抗真菌和抗肿瘤活性。 | |||
T2824 |
Pedunculoside
|
Others; Fatty Acid Synthase | Metabolism; Others |
Pedunculoside 是从 Ilex rotunda Thunb 中提取的,通过对脂质形成和脂肪酸 β-氧化的调节而发挥降脂作用。 | |||
T5S0246 |
Pseudoprotodioscin
山药 |
Others; Fatty Acid Synthase | Metabolism; Others |
Pseudoprotodioscin 是一种呋喃葡糖苷,抑制SREBP1/2和microRNA 33a/b 水平,降低胆固醇和甘油三酯合成相关的基因表达。 | |||
TJS0387 |
Desoxyrhaponticin
去氧土大黄苷,Deoxyrhapontin,脱氧土大黄苷,Deoxyrhaponticin |
Apoptosis; Fatty Acid Synthase | Apoptosis; Metabolism |
Desoxyrhaponticin (Deoxyrhaponticin) 是来自西藏营养食品唐古特大黄中的一种二苯乙烯苷。它是脂肪酸合成酶抑制剂,抑制细胞内 FAS 活性,下调人乳腺癌 MCF-7细胞中 FAS 的表达。它是控制糖尿病餐后高血糖的潜在药物。 | |||
T3121 |
Betulin
Trochol,betulinic alcohol,betuline,betulinol,桦木醇,Betulol,白桦脂醇 |
Apoptosis; Endogenous Metabolite; Lipid; Fatty Acid Synthase | Apoptosis; Metabolism |
Betulin (betulinol) 是从桦树树皮中分离出来的一种天然三萜,是 SREBP 抑制剂。 | |||
T3324 |
Lycorine
Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱 |
Apoptosis; Virus Protease; Antibacterial; AChR; Fatty Acid Synthase | Apoptosis; Metabolism; Microbiology/Virology; Neuroscience |
Lycorine (Narcissine) 是从金眼科植物科中提取的一种天然生物碱。它是一种具有口服活性的SCAP 抑制剂,Kd 值 15.24 nM。它也是黑色素瘤血管生成抑制剂,有用于前列腺癌和代谢疾病的研究潜力。 | |||
T3322 |
trans-Chalcone
Chalcone,反-查耳酮,查尔酮,Cinnamophenone,Chalkone |
Apoptosis; Others; Antifungal; Fatty Acid Synthase | Apoptosis; Metabolism; Microbiology/Virology; Others |
trans-Chalcone (Chalkone) 是从 Aronia melanocarpa 果皮中分离出来的一种天然产物,是类黄酮前体的双酚核心结构。它是脂肪酸合酶和 α-淀粉酶的抑制剂,具有抗真菌和抗癌活性。 | |||
T4S1173 |
Agrimol B
仙鹤草酚B,仙鹤草酚 B |
Sirtuin; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Agrimol B 是从仙鹤草中分离得到的一种多酚衍生物,可抑制脂肪形成,降低PPARγ的表达,诱导SIRT1易位和表达。 | |||
T4S1421 |
Praeruptorin B
Praeruptorin D,(+)-川白芷内酯 |
NPC1L1; Fatty Acid Synthase | Membrane transporter/Ion channel; Metabolism |
Praeruptorin B 是一种固醇调控元件结合蛋白(SREBPs)的抑制剂。 | |||
T2835 |
Morin
桑色素,Toxylon pomiferum,Aurantica,Calico Yellow,Al-Morin |
Others | Others |
Morin (Calico Yellow) 是植物性黄酮类化合物,具有较弱的抗氧化活性,是用于铝物种形成的荧光螯合剂。 | |||
T4S0800 |
Demethyleneberberine
|
P450; NOS; NF-κB; HIF; AMPK | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling |
Demethyleneberberine 是从黄连中提取的一种天然产物,是线粒体靶向抗氧化剂。它也可作为AMPK 激活剂,用于非酒精性脂肪性肝病的研究。它通过抑制NF-κB 通路和调节 Th 细胞的平衡来减轻小鼠结肠炎并抑制炎症反应。 | |||
T29091 |
Valilactone
(-)-Valilactone |
||
Valilactone is a fatty acid synthase inhibitor, which is produced by a cultured strain of soil actinomycetes. | |||
TN1365 |
Albaspidin AP
|
Fatty Acid Synthase | Metabolism |
Albaspidin-AP, -PP, -PB inhibit Fatty acid synthase (FAS) with IC50 values ranging from 23.1+/-1.4 to 71.7+/-3.9 microM, they could be considered to be a promising class of FAS inhibitors, and FAS is emerging as a potential therapeutic target to treat can |